The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic

Transmission electron micrograph of SARS-CoV-2 virus particles

Cell. 2021 Dec 24
doi: 10.1016/j.cell.2021.12.032 [Epub ahead of print]
PMCID: PMC8702401
PMID: 35026151

The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic 

The rapid spread of the SARS-CoV-2 Omicron variant suggests that the virus might become globally dominant. Further, the high number of mutations in the viral spike protein raised concerns that the virus might evade antibodies induced by infection or vaccination. Here, we report that the Omicron spike was resistant against most therapeutic antibodies but remained susceptible to inhibition by sotrovimab. Similarly, the Omicron spike evaded neutralization by antibodies from convalescent patients or individuals vaccinated with the BioNTech-Pfizer vaccine (BNT162b2) with 12- to 44-fold higher efficiency than the spike of the Delta variant. Neutralization of the Omicron spike by antibodies induced upon heterologous ChAdOx1 (Astra Zeneca-Oxford)/BNT162b2 vaccination or vaccination with three doses of BNT162b2 was more efficient, but the Omicron spike still evaded neutralization more efficiently than the Delta spike. These findings indicate that most therapeutic antibodies will be ineffective against the Omicron variant and that double immunization with BNT162b2 might not adequately protect against severe disease induced by this variant.pulsar aquí
 

 

Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019

JAMA Oncology | Original Investigation

 

Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 A Systematic Analysis for the Global Burden of Disease Study 2019.  JAMA Oncol. doi:10.1001/jamaoncol.2021.6987 Published online December 30, 2021. pulsar aquí

IMPORTANCE The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.

Information provision for stroke survivors and their carers (Review)

biblioteca cochrane logo

 

Crocker TF, Brown L, Lam N, Wray F, Knapp P, Forster A. Information provision for stroke survivors and their carers. Cochrane Database of Systematic Reviews 2021, Issue 11. Art. No.: CD001919. DOI: 10.1002/14651858.CD001919.pub4.

Información para los supervivientes de accidentes cerebrovasculares y sus cuidadores. pulsar aquí

Conclusiones de los autores

Proporcionar información de forma activa podría mejorar el conocimiento de los supervivientes de accidentes cerebrovasculares y su calidad de vida, y podría reducir la ansiedad y la depresión. Sin embargo, las reducciones en las puntuaciones de ansiedad y depresión fueron pequeñas y podrían no ser importantes. Por el contrario, proporcionar información de forma pasiva podría empeorar ligeramente las puntuaciones de ansiedad y depresión de los supervivientes de accidentes cerebrovasculares, aunque, de nuevo, se desconoce la importancia de esto. La evidencia relacionada con los cuidadores y otros desenlaces de proporcionar información de manera pasiva es, en general, muy incierta. Aunque todavía se desconoce cuál es la mejor manera de proporcionar información, la evidencia es mejor para las estrategias que implican activamente a los supervivientes de accidentes cerebrovasculares y a sus cuidadores y que incluyen un seguimiento planificado para aclarar y reforzar los conocimientos.

Página 1 de 64

Login Form

logoderecha

  • Última modificación: Miércoles 26 Enero 2022.
Real time web analytics, Heat map tracking